Decrease in PaCO2 with prone position is predictive of improved outcome in acute respiratory distress syndrome.
Identifieur interne : 000490 ( Main/Exploration ); précédent : 000489; suivant : 000491Decrease in PaCO2 with prone position is predictive of improved outcome in acute respiratory distress syndrome.
Auteurs : Luciano Gattinoni [Italie] ; Federica Vagginelli ; Eleonora Carlesso ; Paolo Taccone ; Valeria Conte ; Davide Chiumello ; Franco Valenza ; Pietro Caironi ; Antonio PesentiSource :
- Critical care medicine [ 0090-3493 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Analyse de survie (MeSH), Créatinine (sang), Dioxyde de carbone (sang), Décubitus ventral (MeSH), Espace mort respiratoire (MeSH), Facteurs de risque (MeSH), Facteurs temps (MeSH), Gazométrie sanguine (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Modèles des risques proportionnels (MeSH), Modèles logistiques (MeSH), Pronostic (MeSH), Résultat thérapeutique (MeSH), Soins de réanimation (méthodes), Sujet âgé (MeSH), Syndrome de détresse respiratoire de l'adulte (mortalité), Syndrome de détresse respiratoire de l'adulte (métabolisme), Syndrome de détresse respiratoire de l'adulte (thérapie), Valeur prédictive des tests (MeSH), Ventilation pulmonaire (MeSH), Échanges gazeux pulmonaires (MeSH), Études rétrospectives (MeSH).
- MESH :
- mortalité : Syndrome de détresse respiratoire de l'adulte.
- métabolisme : Syndrome de détresse respiratoire de l'adulte.
- méthodes : Soins de réanimation.
- sang : Créatinine, Dioxyde de carbone.
- thérapie : Syndrome de détresse respiratoire de l'adulte.
- Adulte d'âge moyen, Analyse de survie, Décubitus ventral, Espace mort respiratoire, Facteurs de risque, Facteurs temps, Gazométrie sanguine, Humains, Indice de gravité de la maladie, Modèles des risques proportionnels, Modèles logistiques, Pronostic, Résultat thérapeutique, Sujet âgé, Valeur prédictive des tests, Ventilation pulmonaire, Échanges gazeux pulmonaires, Études rétrospectives.
English descriptors
- KwdEn :
- Aged (MeSH), Blood Gas Analysis (MeSH), Carbon Dioxide (blood), Creatinine (blood), Critical Care (methods), Humans (MeSH), Logistic Models (MeSH), Middle Aged (MeSH), Predictive Value of Tests (MeSH), Prognosis (MeSH), Prone Position (MeSH), Proportional Hazards Models (MeSH), Pulmonary Gas Exchange (MeSH), Pulmonary Ventilation (MeSH), Respiratory Dead Space (MeSH), Respiratory Distress Syndrome, Adult (metabolism), Respiratory Distress Syndrome, Adult (mortality), Respiratory Distress Syndrome, Adult (therapy), Retrospective Studies (MeSH), Risk Factors (MeSH), Severity of Illness Index (MeSH), Survival Analysis (MeSH), Time Factors (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , blood : Carbon Dioxide, Creatinine.
- metabolism : Respiratory Distress Syndrome, Adult.
- methods : Critical Care.
- mortality : Respiratory Distress Syndrome, Adult.
- therapy : Respiratory Distress Syndrome, Adult.
- Aged, Blood Gas Analysis, Humans, Logistic Models, Middle Aged, Predictive Value of Tests, Prognosis, Prone Position, Proportional Hazards Models, Pulmonary Gas Exchange, Pulmonary Ventilation, Respiratory Dead Space, Retrospective Studies, Risk Factors, Severity of Illness Index, Survival Analysis, Time Factors, Treatment Outcome.
Abstract
OBJECTIVE
To determine whether gas exchange improvement in response to the prone position is associated with an improved outcome in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).
DESIGN
Retrospective analysis of patients in the pronation arm of a controlled randomized trial on prone positioning and patients enrolled in a previous pilot study of the prone position.
SETTING
Twenty-eight Italian and two Swiss intensive care units.
PATIENTS
We studied 225 patients meeting the criteria for ALI or ARDS.
INTERVENTIONS
Patients were in prone position for 10 days for 6 hrs/day if they met ALI/ARDS criteria when assessed each morning. Respiratory variables were recorded before and after 6 hrs of pronation with unchanged ventilatory settings.
MEASUREMENTS AND MAIN RESULTS
We measured arterial blood gas alterations to the first pronation and the 28-day mortality rate. The independent risk factors for death in the general population were the Pao2/Fio2 ratio (odds ratio, 0.992; confidence interval, 0.986-0.998), the minute ventilation/Paco2 ratio (odds ratio, 1.003; confidence interval, 1.000-1.006), and the concentration of plasma creatinine (odds ratio, 1.385; confidence interval, 1.116-1.720). Pao2 responders (defined as the patients who increased their Pao2/Fio2 by > or =20 mm Hg, 150 patients, mean increase of 100.6 +/- 61.6 mm Hg [13.4 +/- 8.2 kPa]) had an outcome similar to the nonresponders (59 patients, mean decrease -6.3 +/- 23.7 mm Hg [-0.8 +/- 3.2 kPa]; mortality rate 44% and 46%, respectively; relative risk, 1.04; confidence interval, 0.74-1.45, p =.65). The Paco2 responders (defined as patients whose Paco2 decreased by > or =1 mm Hg, 94 patients, mean decrease -6.0 +/- 6 mm Hg [-0.8 +/- 0.8 kPa]) had an improved survival when compared with nonresponders (115 patients, mean increase 6 +/- 6 mm Hg [0.8 +/- 0.8 kPa]; mortality rate 35.1% and 52.2%, respectively; relative risk, 1.48; confidence interval, 1.07-2.05, p =.01).
CONCLUSION
ALI/ARDS patients who respond to prone positioning with reduction of their Paco2 show an increased survival at 28 days. Improved efficiency of alveolar ventilation (decreased physiologic deadspace ratio) is an important marker of patients who will survive acute respiratory failure.
DOI: 10.1097/01.CCM.0000098032.34052.F9
PubMed: 14668608
Affiliations:
Links toward previous steps (curation, corpus...)
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wicri:level="3"><nlm:affiliation>Istituto di Anestesia e Rianimazione, Universitá degli Studi di Milano, Ospedale Policlinico, Milan, Italy. gattinon@policlinico.mi.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Anestesia e Rianimazione, Universitá degli Studi di Milano, Ospedale Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Vagginelli, Federica" sort="Vagginelli, Federica" uniqKey="Vagginelli F" first="Federica" last="Vagginelli">Federica Vagginelli</name></author><author><name sortKey="Carlesso, Eleonora" sort="Carlesso, Eleonora" uniqKey="Carlesso E" first="Eleonora" last="Carlesso">Eleonora Carlesso</name></author><author><name sortKey="Taccone, Paolo" sort="Taccone, Paolo" uniqKey="Taccone P" first="Paolo" last="Taccone">Paolo Taccone</name></author><author><name sortKey="Conte, Valeria" sort="Conte, Valeria" uniqKey="Conte V" first="Valeria" last="Conte">Valeria Conte</name></author><author><name sortKey="Chiumello, Davide" sort="Chiumello, Davide" uniqKey="Chiumello D" first="Davide" last="Chiumello">Davide Chiumello</name></author><author><name sortKey="Valenza, Franco" sort="Valenza, Franco" uniqKey="Valenza F" first="Franco" last="Valenza">Franco Valenza</name></author><author><name sortKey="Caironi, Pietro" sort="Caironi, Pietro" uniqKey="Caironi P" first="Pietro" last="Caironi">Pietro Caironi</name></author><author><name sortKey="Pesenti, Antonio" sort="Pesenti, Antonio" uniqKey="Pesenti A" first="Antonio" last="Pesenti">Antonio Pesenti</name></author></analytic><series><title level="j">Critical care medicine</title><idno type="ISSN">0090-3493</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Blood Gas Analysis (MeSH)</term><term>Carbon Dioxide (blood)</term><term>Creatinine (blood)</term><term>Critical Care (methods)</term><term>Humans (MeSH)</term><term>Logistic Models (MeSH)</term><term>Middle Aged (MeSH)</term><term>Predictive Value of Tests (MeSH)</term><term>Prognosis (MeSH)</term><term>Prone Position (MeSH)</term><term>Proportional Hazards Models (MeSH)</term><term>Pulmonary Gas Exchange (MeSH)</term><term>Pulmonary Ventilation (MeSH)</term><term>Respiratory Dead Space (MeSH)</term><term>Respiratory Distress Syndrome, Adult (metabolism)</term><term>Respiratory Distress Syndrome, Adult (mortality)</term><term>Respiratory Distress Syndrome, Adult (therapy)</term><term>Retrospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term><term>Severity of Illness Index (MeSH)</term><term>Survival Analysis (MeSH)</term><term>Time Factors (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Analyse de survie (MeSH)</term><term>Créatinine (sang)</term><term>Dioxyde de carbone (sang)</term><term>Décubitus ventral (MeSH)</term><term>Espace mort respiratoire (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Facteurs temps (MeSH)</term><term>Gazométrie sanguine (MeSH)</term><term>Humains (MeSH)</term><term>Indice de gravité de la maladie (MeSH)</term><term>Modèles des risques proportionnels (MeSH)</term><term>Modèles logistiques (MeSH)</term><term>Pronostic (MeSH)</term><term>Résultat thérapeutique (MeSH)</term><term>Soins de réanimation (méthodes)</term><term>Sujet âgé (MeSH)</term><term>Syndrome de détresse respiratoire de l'adulte (mortalité)</term><term>Syndrome de détresse respiratoire de l'adulte (métabolisme)</term><term>Syndrome de détresse respiratoire de l'adulte (thérapie)</term><term>Valeur prédictive des tests (MeSH)</term><term>Ventilation pulmonaire (MeSH)</term><term>Échanges gazeux pulmonaires (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Carbon Dioxide</term><term>Creatinine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Critical Care</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Soins de réanimation</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Créatinine</term><term>Dioxyde de carbone</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Blood Gas Analysis</term><term>Humans</term><term>Logistic Models</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prognosis</term><term>Prone Position</term><term>Proportional Hazards Models</term><term>Pulmonary Gas Exchange</term><term>Pulmonary Ventilation</term><term>Respiratory Dead Space</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Survival Analysis</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Décubitus ventral</term><term>Espace mort respiratoire</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Gazométrie sanguine</term><term>Humains</term><term>Indice de gravité de la maladie</term><term>Modèles des risques proportionnels</term><term>Modèles logistiques</term><term>Pronostic</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Valeur prédictive des tests</term><term>Ventilation pulmonaire</term><term>Échanges gazeux pulmonaires</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To determine whether gas exchange improvement in response to the prone position is associated with an improved outcome in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>Retrospective analysis of patients in the pronation arm of a controlled randomized trial on prone positioning and patients enrolled in a previous pilot study of the prone position.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING</b></p><p>Twenty-eight Italian and two Swiss intensive care units.</p></div><div type="abstract" xml:lang="en"><p><b>PATIENTS</b></p><p>We studied 225 patients meeting the criteria for ALI or ARDS.</p></div><div type="abstract" xml:lang="en"><p><b>INTERVENTIONS</b></p><p>Patients were in prone position for 10 days for 6 hrs/day if they met ALI/ARDS criteria when assessed each morning. Respiratory variables were recorded before and after 6 hrs of pronation with unchanged ventilatory settings.</p></div><div type="abstract" xml:lang="en"><p><b>MEASUREMENTS AND MAIN RESULTS</b></p><p>We measured arterial blood gas alterations to the first pronation and the 28-day mortality rate. The independent risk factors for death in the general population were the Pao2/Fio2 ratio (odds ratio, 0.992; confidence interval, 0.986-0.998), the minute ventilation/Paco2 ratio (odds ratio, 1.003; confidence interval, 1.000-1.006), and the concentration of plasma creatinine (odds ratio, 1.385; confidence interval, 1.116-1.720). Pao2 responders (defined as the patients who increased their Pao2/Fio2 by > or =20 mm Hg, 150 patients, mean increase of 100.6 +/- 61.6 mm Hg [13.4 +/- 8.2 kPa]) had an outcome similar to the nonresponders (59 patients, mean decrease -6.3 +/- 23.7 mm Hg [-0.8 +/- 3.2 kPa]; mortality rate 44% and 46%, respectively; relative risk, 1.04; confidence interval, 0.74-1.45, p =.65). The Paco2 responders (defined as patients whose Paco2 decreased by > or =1 mm Hg, 94 patients, mean decrease -6.0 +/- 6 mm Hg [-0.8 +/- 0.8 kPa]) had an improved survival when compared with nonresponders (115 patients, mean increase 6 +/- 6 mm Hg [0.8 +/- 0.8 kPa]; mortality rate 35.1% and 52.2%, respectively; relative risk, 1.48; confidence interval, 1.07-2.05, p =.01).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>ALI/ARDS patients who respond to prone positioning with reduction of their Paco2 show an increased survival at 28 days. Improved efficiency of alveolar ventilation (decreased physiologic deadspace ratio) is an important marker of patients who will survive acute respiratory failure.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14668608</PMID><DateCompleted><Year>2004</Year><Month>01</Month><Day>16</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0090-3493</ISSN><JournalIssue CitedMedium="Print"><Volume>31</Volume><Issue>12</Issue><PubDate><Year>2003</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Critical care medicine</Title></Journal><ArticleTitle>Decrease in PaCO2 with prone position is predictive of improved outcome in acute respiratory distress syndrome.</ArticleTitle><Pagination><MedlinePgn>2727-33</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine whether gas exchange improvement in response to the prone position is associated with an improved outcome in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Retrospective analysis of patients in the pronation arm of a controlled randomized trial on prone positioning and patients enrolled in a previous pilot study of the prone position.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Twenty-eight Italian and two Swiss intensive care units.</AbstractText><AbstractText Label="PATIENTS" NlmCategory="METHODS">We studied 225 patients meeting the criteria for ALI or ARDS.</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">Patients were in prone position for 10 days for 6 hrs/day if they met ALI/ARDS criteria when assessed each morning. Respiratory variables were recorded before and after 6 hrs of pronation with unchanged ventilatory settings.</AbstractText><AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">We measured arterial blood gas alterations to the first pronation and the 28-day mortality rate. The independent risk factors for death in the general population were the Pao2/Fio2 ratio (odds ratio, 0.992; confidence interval, 0.986-0.998), the minute ventilation/Paco2 ratio (odds ratio, 1.003; confidence interval, 1.000-1.006), and the concentration of plasma creatinine (odds ratio, 1.385; confidence interval, 1.116-1.720). Pao2 responders (defined as the patients who increased their Pao2/Fio2 by > or =20 mm Hg, 150 patients, mean increase of 100.6 +/- 61.6 mm Hg [13.4 +/- 8.2 kPa]) had an outcome similar to the nonresponders (59 patients, mean decrease -6.3 +/- 23.7 mm Hg [-0.8 +/- 3.2 kPa]; mortality rate 44% and 46%, respectively; relative risk, 1.04; confidence interval, 0.74-1.45, p =.65). The Paco2 responders (defined as patients whose Paco2 decreased by > or =1 mm Hg, 94 patients, mean decrease -6.0 +/- 6 mm Hg [-0.8 +/- 0.8 kPa]) had an improved survival when compared with nonresponders (115 patients, mean increase 6 +/- 6 mm Hg [0.8 +/- 0.8 kPa]; mortality rate 35.1% and 52.2%, respectively; relative risk, 1.48; confidence interval, 1.07-2.05, p =.01).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">ALI/ARDS patients who respond to prone positioning with reduction of their Paco2 show an increased survival at 28 days. Improved efficiency of alveolar ventilation (decreased physiologic deadspace ratio) is an important marker of patients who will survive acute respiratory failure.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gattinoni</LastName><ForeName>Luciano</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Istituto di Anestesia e Rianimazione, Universitá degli Studi di Milano, Ospedale Policlinico, Milan, Italy. gattinon@policlinico.mi.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vagginelli</LastName><ForeName>Federica</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Carlesso</LastName><ForeName>Eleonora</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Taccone</LastName><ForeName>Paolo</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Conte</LastName><ForeName>Valeria</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Chiumello</LastName><ForeName>Davide</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Valenza</LastName><ForeName>Franco</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Caironi</LastName><ForeName>Pietro</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Pesenti</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><CollectiveName>Prone-Supine Study Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Crit Care Med</MedlineTA><NlmUniqueID>0355501</NlmUniqueID><ISSNLinking>0090-3493</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>142M471B3J</RegistryNumber><NameOfSubstance UI="D002245">Carbon Dioxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>AYI8EX34EU</RegistryNumber><NameOfSubstance UI="D003404">Creatinine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care Med. 2003 Dec;31(12):2804-5</RefSource><PMID Version="1">14668619</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care Med. 2004 Jun;32(6):1441</RefSource><PMID Version="1">15187555</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care Med. 2005 Oct;33(10):2448; author reply 2448-9</RefSource><PMID Version="1">16215423</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001784" MajorTopicYN="Y">Blood Gas Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002245" MajorTopicYN="N">Carbon Dioxide</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003404" MajorTopicYN="N">Creatinine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003422" MajorTopicYN="N">Critical Care</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016684" MajorTopicYN="Y">Prone Position</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011659" MajorTopicYN="Y">Pulmonary Gas Exchange</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012123" MajorTopicYN="N">Pulmonary Ventilation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012126" MajorTopicYN="N">Respiratory Dead Space</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>12</Month><Day>12</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>1</Month><Day>17</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>12</Month><Day>12</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14668608</ArticleId><ArticleId IdType="doi">10.1097/01.CCM.0000098032.34052.F9</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><noCountry><name sortKey="Caironi, Pietro" sort="Caironi, Pietro" uniqKey="Caironi P" first="Pietro" last="Caironi">Pietro Caironi</name><name sortKey="Carlesso, Eleonora" sort="Carlesso, Eleonora" uniqKey="Carlesso E" first="Eleonora" last="Carlesso">Eleonora Carlesso</name><name sortKey="Chiumello, Davide" sort="Chiumello, Davide" uniqKey="Chiumello D" first="Davide" last="Chiumello">Davide Chiumello</name><name sortKey="Conte, Valeria" sort="Conte, Valeria" uniqKey="Conte V" first="Valeria" last="Conte">Valeria Conte</name><name sortKey="Pesenti, Antonio" sort="Pesenti, Antonio" uniqKey="Pesenti A" first="Antonio" last="Pesenti">Antonio Pesenti</name><name sortKey="Taccone, Paolo" sort="Taccone, Paolo" uniqKey="Taccone P" first="Paolo" last="Taccone">Paolo Taccone</name><name sortKey="Vagginelli, Federica" sort="Vagginelli, Federica" uniqKey="Vagginelli F" first="Federica" last="Vagginelli">Federica Vagginelli</name><name sortKey="Valenza, Franco" sort="Valenza, Franco" uniqKey="Valenza F" first="Franco" last="Valenza">Franco Valenza</name></noCountry><country name="Italie"><region name="Lombardie"><name sortKey="Gattinoni, Luciano" sort="Gattinoni, Luciano" uniqKey="Gattinoni L" first="Luciano" last="Gattinoni">Luciano Gattinoni</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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